HOXB7

Across TCGA pan-cancer cohorts, HOXB7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HOXB7 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HOXB7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HOXB7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, LIHC, and UCEC are the cancer types where HOXB7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.164	0.675	.018	21	view →
LIHC	OS	Median	II,III,IV	0.125	0.719	<.001	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.033	10	view →
SARC	DFS	Median	All	0.094	0.611	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HOXB7–LUSC (OS)

Open the LUSC breakdown →