HOXB7

Across TCGA patient cohorts, HOXB7 mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB7-associated genes across cancer lineages are Skeletal muscle, Erythrocytes, and Mesangial cells. Each is linked with HOXB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB7-to-partner and partner-to-HOXB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Skeletal muscle grouped by HOXB7-low versus HOXB7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB7→partner) and Y-score (partner→HOXB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Skeletal muscle →	+0.046	+2.470	.027	.011	3	2
UCEC	Erythrocytes →	+0.052	+2.241	<.001	.031	3	1
UCEC	Mesangial cells →	-0.056	-3.305	.002	.010	3	1
UCEC	mv Endothelial cells →	-0.032	-3.574	.005	.003	3	1
UCEC	Myocytes →	+0.050	+2.823	.001	.036	2	2
UCEC	pro B-cells →	+0.117	+3.016	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Skeletal muscle by HOXB7 expression — UCEC

Explore this box plot interactively →