HOXB6

Across TCGA patient cohorts, HOXB6 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,189 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOXB6-associated proteins across cancer lineages are SFRP4, HOXB6_S214, and MUC1. Each is linked with HOXB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOXB6-to-partner and partner-to-HOXB6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB6 versus SFRP4 in PDAC, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB6→partner) and Y-score (partner→HOXB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SFRP4 →	+0.857	+0.781	.001	<.001	3	4
LSCC	HOXB6_S214 →	+1.122	+1.196	<.001	<.001	3	4
HNSC	MUC1 →	+0.765	+0.684	<.001	.005	3	3
UCEC	GCC2 →	+0.181	+1.022	.004	.007	3	3
HNSC	KIF1A →	+1.147	+1.893	.001	<.001	3	3
UCEC	THEMIS2 →	-0.348	-1.180	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,189 associations by consensus.

HOXB6 vs SFRP4 — PDAC

Explore this scatter interactively →