HOXB6

Across TCGA patient cohorts, HOXB6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB6-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and p62 Lck ligand. Each is linked with HOXB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB6-to-partner and partner-to-HOXB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HOXB6-low versus HOXB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB6→partner) and Y-score (partner→HOXB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.360	-3.169	.004	.018	3	1
UCEC	A-Raf_pS299 →	-0.200	-3.169	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.539	+3.009	<.001	.019	3	1
UCEC	TFRC →	+0.649	+2.321	.014	.035	3	1
UCEC	4E-BP1 →	+0.408	+3.029	.002	.018	3	1
UCEC	BRD4 →	+0.321	+2.818	.022	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by HOXB6 expression — UCEC

Explore this box plot interactively →