HOXB6

Across TCGA cell cohorts, HOXB6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXB6-associated genes across cancer lineages are MAJIN, ACTRT2, and OR4B1. Each is linked with HOXB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB6-to-partner and partner-to-HOXB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAJIN grouped by HOXB6-low versus HOXB6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB6→partner) and Y-score (partner→HOXB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAJIN →	+0.086	+3.876	.008	.003	3	1
LARGE_INTESTINE	ACTRT2 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR4B1 →	+0.020	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF27 →	+0.003	+4.022	<.001	.006	3	1
LUNG_NSCLC_LUAD	SPACA5B →	+0.042	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAJIN by HOXB6 expression — LARGE_INTESTINE

Explore this box plot interactively →