HOXB5

Across TCGA patient cohorts, HOXB5 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB5-associated genes across cancer lineages are LCE2B, PSAT1P4, and MS4A5. Each is linked with HOXB5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB5-to-partner and partner-to-HOXB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE2B grouped by HOXB5-low versus HOXB5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB5→partner) and Y-score (partner→HOXB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LCE2B →	+1.773	+3.476	.007	.005	3	3
BLCA	PSAT1P4 →	+0.078	+5.038	<.001	.009	3	2
LUAD	MS4A5 →	+0.455	+4.510	<.001	.005	3	2
LUAD	SNORD114-13 →	+0.506	+4.554	.001	.009	3	2
LUAD	SLC6A17-AS1 →	+0.054	+4.554	<.001	.009	3	2
LUAD	MIR4476 →	+0.529	+5.087	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

LCE2B by HOXB5 expression — SKCM

Explore this box plot interactively →