HOXB5

Across TCGA pan-cancer cohorts, HOXB5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated HOXB5 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXB5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXB5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

ACC, BLCA, and KIRP are the cancer types where HOXB5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.246	0.644	<.001	105	view →
BLCA	OS	Tertile	All	0.531	0.304	<.001	79	view →
KIRP	OS	Median	III,IV	0.184	0.784	.003	49	view →
LGG	OS	Median	All	0.731	0.869	<.001	48	view →
LUAD	DFS	Tertile	III,IV	0.283	0.622	.002	47	view →
LUSC	OS	Tertile	All	0.303	0.465	.003	40	view →
UCEC	OS	Tertile	All	0.956	0.891	<.001	36	view →
LAML	DFS	Median	All	0.433	0.711	.005	32	view →
COAD	DFS	Quartile	All	0.285	0.656	<.001	29	view →
THCA	OS	Tertile	III,IV	0.929	1.000	.015	27	view →
HNSC	DFS	Quartile	All	0.523	0.766	.004	27	view →
MESO	OS	Quartile	II,III,IV	0.227	0.454	.014	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

HOXB5–ACC (DFS)

Open the ACC breakdown →