HOXB5

Across TCGA cell cohorts, HOXB5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,643 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HOXB5-associated GO terms across cancer lineages are Anterior/posterior pattern specification, Pre-mRNA catabolic process, and mRNA cis splicing, via spliceosome. Each is linked with HOXB5 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOXB5-to-partner and partner-to-HOXB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anterior/posterior pattern specification grouped by HOXB5-low versus HOXB5-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB5→partner) and Y-score (partner→HOXB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Anterior/posterior pattern specification →	+0.051	+1.447	.002	<.001	3	9
SKIN	Pre-mRNA catabolic process →	+0.163	+1.187	<.001	<.001	3	6
URINARY_TRACT	mRNA cis splicing, via spliceosome →	+0.116	+1.503	<.001	.001	3	6
STOMACH	Regionalization →	+0.029	+1.166	.001	.002	3	6
SKIN	Microtubule nucleation →	+0.099	+1.365	<.001	<.001	3	5
LUNG_SCLC	Regulation of respiratory gaseous exchange →	+0.222	+2.913	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,643 associations by consensus.

Anterior/posterior pattern specification by HOXB5 expression — KIDNEY

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