HOXB13

Across TCGA patient cohorts, HOXB13 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,076 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXB13-associated proteins across cancer lineages are USP39, RCOR3, and KIF1A_S1370. Each is linked with HOXB13 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOXB13-to-partner and partner-to-HOXB13 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB13 versus USP39 in LSCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB13→partner) and Y-score (partner→HOXB13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP39 →	+0.306	+1.118	<.001	<.001	3	4
HNSC	RCOR3 →	+0.373	+0.928	<.001	<.001	3	4
LUAD	KIF1A_S1370 →	+2.041	+0.956	<.001	.001	3	4
BRCA	NUP153_T699 →	+0.542	+1.134	.004	<.001	3	3
CCRCC	PEBP1 →	-0.324	-0.606	<.001	<.001	3	3
BRCA	PHYHD1 →	-0.572	-0.846	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,076 associations by consensus.

HOXB13 vs USP39 — LSCC

Explore this scatter interactively →