HOXB13

Across TCGA pan-cancer cohorts, HOXB13 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HOXB13’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HOXB13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXB13 is over-expressed in tumor, although a few such as READ and THCA show the opposite, repressed pattern.

KIRP, BRCA, and STAD are the cancer types where HOXB13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+1.342	<.001	9	view →
BRCA	All	IV	+4.570	<.001	8	view →
STAD	All	II,III,IV	+2.091	<.001	8	view →
HNSC	Male	All	+0.984	<.001	8	view →
KIRC	All	All	+0.515	.001	8	view →
UCEC	All	All	+2.273	<.001	6	view →
LUSC	Male	All	+1.713	<.001	6	view →
LUAD	Female	All	+1.140	<.001	6	view →
PAAD	All	All	+0.970	.019	4	view →
LIHC	Female	All	+0.386	.014	4	view →
CHOL	Male	All	+1.928	.040	3	view →
PRAD	All	All	+1.509	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HOXB13–KIRP

Open the KIRP breakdown →