HOXB13

Across TCGA patient cohorts, HOXB13 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB13-associated genes across cancer lineages are Fibronectin, IGFBP2, and MEK1. Each is linked with HOXB13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB13-to-partner and partner-to-HOXB13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by HOXB13-low versus HOXB13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB13→partner) and Y-score (partner→HOXB13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.299	-2.321	.028	.006	3	1
UCEC	IGFBP2 →	-0.576	-1.807	.031	.027	3	1
UCEC	MEK1 →	+0.385	+1.807	.010	.027	3	1
UCEC	Notch1 →	+0.147	+3.013	.011	.018	3	1
UCEC	Tuberin →	+0.247	+1.807	.026	.027	3	1
UCEC	Caspase-8 →	-0.264	-4.087	.011	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Fibronectin by HOXB13 expression — UCEC

Explore this box plot interactively →