HOXB13

Across TCGA cell cohorts, HOXB13 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,991 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXB13-associated GO terms across cancer lineages are Cellular respiration, Purine nucleotide biosynthetic process, and Aerobic electron transport chain. Each is linked with HOXB13 in more than 9 cancer types. Because this analysis shows association rather than direction, both HOXB13-to-partner and partner-to-HOXB13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular respiration grouped by HOXB13-low versus HOXB13-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB13→partner) and Y-score (partner→HOXB13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cellular respiration →	+0.078	+1.418	<.001	<.001	3	9
SKIN	Purine nucleotide biosynthetic process →	+0.058	+1.362	<.001	.001	2	10
PANCREAS	Aerobic electron transport chain →	+0.092	+1.051	<.001	.002	3	9
PANCREAS	ATP synthesis coupled electron transport →	+0.093	+1.170	<.001	<.001	3	9
PANCREAS	Mitochondrial ATP synthesis coupled electron transport →	+0.093	+1.170	<.001	<.001	3	9
SKIN	Purine nucleoside triphosphate biosynthetic process →	+0.091	+1.914	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,991 associations by consensus.

Cellular respiration by HOXB13 expression — SKIN

Explore this box plot interactively →