HOXB13

Across TCGA cell cohorts, HOXB13 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HOXB13-associated genes across cancer lineages are BIRC8, OR2T2, and DYNAP. Each is linked with HOXB13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB13-to-partner and partner-to-HOXB13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIRC8 grouped by HOXB13-low versus HOXB13-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB13→partner) and Y-score (partner→HOXB13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BIRC8 →	+0.012	+4.977	<.001	.007	3	1
SKIN	OR2T2 →	+0.013	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1
LUNG_NSCLC_LUAD	C9orf92 →	+0.196	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR2F2 →	+0.027	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR13C7 →	+0.037	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

BIRC8 by HOXB13 expression — SKIN

Explore this box plot interactively →