HOXB1

Across TCGA pan-cancer cohorts, HOXB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HOXB1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HOXB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HOXB1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where HOXB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.513	0.237	<.001	90	view →
LUAD	OS	Tertile	All	0.507	0.939	.002	46	view →
CCRCC	OS	Quartile	III,IV	0.930	0.446	.011	18	view →
LSCC	DFS	Median	II,III,IV	0.882	0.674	.025	4	view →
HNSC	OS	Tertile	III,IV	1.000	0.339	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HOXB1–PDAC (DFS)

Open the PDAC breakdown →