HOXB1

Across TCGA pan-cancer cohorts, HOXB1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HOXB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXB1 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXB1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BRCA are the cancer types where HOXB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.410	<.001	12	view →
KIRP	Male	All	−0.340	<.001	11	view →
BRCA	All	II,III,IV	+0.218	<.001	6	view →
LUSC	All	All	+0.167	<.001	4	view →
PAAD	All	All	+0.224	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HOXB1–KIRC

Open the KIRC breakdown →