HOXB1

Across TCGA patient cohorts, HOXB1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,511 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXB1-associated genes across cancer lineages are TACC2, PGAP4, and PLAU. Each is linked with HOXB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HOXB1-to-partner and partner-to-HOXB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB1 versus TACC2 in LSCC, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB1→partner) and Y-score (partner→HOXB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TACC2 →	+1.193	+1.195	<.001	<.001	3	6
LSCC	PGAP4 →	+1.361	+1.133	<.001	<.001	3	5
LUAD	PLAU →	-1.456	-0.908	<.001	<.001	3	4
HNSC	HIVEP3 →	-0.733	-0.866	<.001	<.001	3	4
LUAD	SLC43A3 →	-0.703	-0.795	<.001	.001	3	4
HNSC	DCBLD1 →	-0.869	-1.006	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,511 associations by consensus.

HOXB1 vs TACC2 — LSCC

Explore this scatter interactively →