HOXB1

Across TCGA patient cohorts, HOXB1 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HOXB1-associated genes across cancer lineages are SLC25A15P1, RNU4-88P, and MIR378E. Each is linked with HOXB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB1-to-partner and partner-to-HOXB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A15P1 grouped by HOXB1-low versus HOXB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB1→partner) and Y-score (partner→HOXB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC25A15P1 →	+0.097	+2.459	.002	.009	3	3
COAD	RNU4-88P →	+0.468	+5.734	<.001	<.001	3	2
COAD	MIR378E →	+0.562	+4.721	<.001	.004	3	2
COAD	MIR5583-1 →	+0.465	+4.917	<.001	.003	3	2
SKCM	TINAG →	+0.102	+1.810	<.001	.008	3	2
BRCA	RNA5SP326 →	+0.218	+8.055	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

SLC25A15P1 by HOXB1 expression — SKCM

Explore this box plot interactively →