HOXB1

Across TCGA patient cohorts, HOXB1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB1-associated genes across cancer lineages are c-Met_pY1235, Stathmin, and Heregulin. Each is linked with HOXB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB1-to-partner and partner-to-HOXB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by HOXB1-low versus HOXB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB1→partner) and Y-score (partner→HOXB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.110	+3.000	.010	.037	3	3
SKCM	Stathmin →	+0.293	+3.025	<.001	.018	3	2
SKCM	Heregulin →	+0.298	+3.012	<.001	.018	3	1
SKCM	PI3K-p110-a →	+0.183	+3.459	.016	.005	3	1
SKCM	YB-1 →	-0.227	-3.459	.027	.005	3	1
SKCM	Bim →	-0.358	-3.000	.006	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

c-Met_pY1235 by HOXB1 expression — UCEC

Explore this box plot interactively →