HOXB1

Across TCGA cell cohorts, HOXB1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HOXB1-associated genes across cancer lineages are DEFA3, OR1L3, and UCN3. Each is linked with HOXB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB1-to-partner and partner-to-HOXB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA3 grouped by HOXB1-low versus HOXB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB1→partner) and Y-score (partner→HOXB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	UCN3 →	+0.055	+4.977	<.001	.007	3	1
SKIN	TFAP2D →	+0.189	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	MT1H →	+0.928	+3.866	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

DEFA3 by HOXB1 expression — LARGE_INTESTINE

Explore this box plot interactively →