HOXB-AS3

Across TCGA pan-cancer cohorts, HOXB-AS3 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated HOXB-AS3 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HOXB-AS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXB-AS3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

KIRP, KIRC, and ACC are the cancer types where HOXB-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	III,IV	0.190	0.655	<.001	103	view →
KIRC	DFS	Quartile	II,III,IV	0.354	0.690	<.001	78	view →
ACC	DFS	Median	All	0.283	0.625	.001	67	view →
LGG	DFS	Tertile	All	0.580	0.793	<.001	54	view →
BLCA	OS	Tertile	All	0.797	0.666	.004	43	view →
HNSC	OS	Median	IV	0.512	0.329	.002	36	view →
LUSC	OS	Quartile	II,III,IV	0.297	0.543	.005	34	view →
UCEC	OS	Tertile	All	0.955	0.893	.001	34	view →
COAD	OS	Tertile	II,III,IV	0.919	0.666	<.001	30	view →
LAML	DFS	Median	All	0.250	0.492	.002	20	view →
ESCA	OS	Tertile	All	0.456	1.000	.008	19	view →
LIHC	OS	Quartile	All	0.636	0.279	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

HOXB-AS3–KIRP (OS)

Open the KIRP breakdown →