HOXB-AS3

Across TCGA pan-cancer cohorts, HOXB-AS3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HOXB-AS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXB-AS3 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXB-AS3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where HOXB-AS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB-AS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.103	<.001	12	view →
HNSC	All	II,III,IV	+0.193	<.001	10	view →
BLCA	All	III,IV	+0.732	.003	8	view →
KIRP	Male	All	−2.106	<.001	7	view →
LUSC	All	III,IV	−1.430	<.001	7	view →
LUAD	All	All	−0.405	.003	6	view →
BRCA	Female	II,III,IV	+0.477	.009	4	view →
KICH	Male	All	−0.888	.003	3	view →
CHOL	Female	All	+0.346	.003	3	view →
PRAD	All	All	−0.723	.001	2	view →
COAD	Female	IV	+0.430	.025	1	view →
LIHC	All	All	+0.136	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HOXB-AS3–KIRC

Open the KIRC breakdown →