HOXB-AS2

Across TCGA pan-cancer cohorts, HOXB-AS2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HOXB-AS2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HOXB-AS2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HOXB-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, KIRP, and LGG are the cancer types where HOXB-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.796	0.554	<.001	66	view →
KIRP	DFS	Median	II,III,IV	0.276	0.718	.003	57	view →
LGG	OS	Tertile	All	0.203	0.494	<.001	54	view →
THCA	OS	Tertile	II,III,IV	0.712	0.953	<.001	44	view →
COAD	DFS	Tertile	All	0.400	0.664	.001	30	view →
BLCA	OS	Median	All	0.543	0.330	.006	26	view →
KIRC	DFS	Quartile	All	0.838	0.505	<.001	22	view →
LAML	DFS	Tertile	All	0.504	0.706	.017	20	view →
BRCA	DFS	Quartile	IV	0.890	0.233	.008	16	view →
STAD	OS	Tertile	II,III,IV	0.677	0.441	.019	15	view →
LUAD	OS	Quartile	II,III,IV	0.816	0.641	.004	13	view →
MESO	DFS	Quartile	All	0.262	0.786	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HOXB-AS2–HNSC (DFS)

Open the HNSC breakdown →