HOXB-AS2

Across TCGA pan-cancer cohorts, HOXB-AS2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HOXB-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXB-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXB-AS2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where HOXB-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.251	<.001	12	view →
KIRP	Male	All	−0.899	<.001	6	view →
THCA	Female	All	−0.109	.001	3	view →
LUSC	All	III,IV	−0.636	.015	2	view →
PRAD	All	All	−0.549	<.001	2	view →
COAD	All	IV	+1.158	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HOXB-AS2–KIRC

Open the KIRC breakdown →