HOXB-AS1

Across TCGA pan-cancer cohorts, HOXB-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HOXB-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher HOXB-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HOXB-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and CESC show a favorable association.

MESO, UVM, and KIRC are the cancer types where HOXB-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.540	0.239	<.001	125	view →
UVM	DFS	Quartile	All	0.349	0.765	<.001	94	view →
KIRC	DFS	Tertile	II,III,IV	0.368	0.642	<.001	87	view →
LGG	DFS	Median	All	0.630	0.829	<.001	51	view →
CESC	OS	Tertile	IV	0.726	0.073	.002	36	view →
COAD	DFS	Quartile	All	0.284	0.649	.002	35	view →
HNSC	DFS	Median	III,IV	0.406	0.243	.004	35	view →
CHOL	DFS	Median	II,III,IV	0.690	0.151	.004	33	view →
LAML	DFS	Tertile	All	0.270	0.538	.003	28	view →
READ	DFS	Tertile	III,IV	0.342	0.977	.001	27	view →
PRAD	DFS	Quartile	All	0.780	0.917	.001	26	view →
ACC	DFS	Median	II,III,IV	0.218	0.607	.009	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HOXB-AS1–MESO (OS)

Open the MESO breakdown →