HOXB-AS1

Across TCGA pan-cancer cohorts, HOXB-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HOXB-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXB-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXB-AS1 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where HOXB-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.725	<.001	11	view →
LIHC	All	All	+0.279	.003	7	view →
BRCA	All	II,III,IV	−1.198	<.001	6	view →
CHOL	All	All	+0.692	.001	5	view →
KICH	All	All	−0.884	<.001	4	view →
KIRP	All	II,III,IV	+0.608	.010	4	view →
THCA	Female	II,III,IV	−0.383	.007	2	view →
PRAD	All	All	−0.375	<.001	2	view →
LUSC	Male	III,IV	−0.820	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HOXB-AS1–KIRC

Open the KIRC breakdown →