HOXA9

Across TCGA patient cohorts, HOXA9 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA9-associated genes across cancer lineages are MSH6, 14-3-3_beta, and eIF4E. Each is linked with HOXA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA9-to-partner and partner-to-HOXA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by HOXA9-low versus HOXA9-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA9→partner) and Y-score (partner→HOXA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MSH6 →	+0.445	+2.832	.009	.034	2	2
UCEC	14-3-3_beta →	-0.082	-2.432	.033	.018	3	1
UCEC	eIF4E →	+0.175	+1.678	.030	.023	3	1
UCEC	A-Raf_pS299 →	-0.114	-1.678	.012	.023	3	1
UCEC	JNK2 →	+0.272	+2.331	<.001	.003	3	1
UCEC	Ku80 →	+0.237	+1.691	.008	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MSH6 by HOXA9 expression — LUAD

Explore this box plot interactively →