HOXA9

Across TCGA pan-cancer cohorts, HOXA9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HOXA9’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HOXA9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXA9 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

COAD, UCEC, and BRCA are the cancer types where HOXA9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.548	<.001	10	view →
UCEC	All	II,III,IV	+3.231	<.001	6	view →
BRCA	All	All	−1.658	<.001	6	view →
STAD	All	All	+0.962	<.001	6	view →
KIRC	Male	All	−0.557	<.001	6	view →
LUAD	All	All	+0.395	.007	6	view →
HNSC	All	All	+0.710	.003	5	view →
LUSC	All	All	+0.576	.001	4	view →
LIHC	All	All	+0.091	.004	3	view →
THCA	All	II,III,IV	−0.070	.003	3	view →
READ	Male	All	−1.390	.042	2	view →
PRAD	All	All	+0.665	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HOXA9–COAD

Open the COAD breakdown →