HOXA9

Across TCGA cell cohorts, HOXA9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,674 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXA9-associated GO terms across cancer lineages are Embryonic skeletal joint morphogenesis, Regulation of epidermal growth factor receptor signaling pathway, and Proximal/distal pattern formation. Each is linked with HOXA9 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOXA9-to-partner and partner-to-HOXA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic skeletal joint morphogenesis grouped by HOXA9-low versus HOXA9-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA9→partner) and Y-score (partner→HOXA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Embryonic skeletal joint morphogenesis →	-0.240	-0.886	<.001	<.001	3	9
BONE	Regulation of epidermal growth factor receptor signaling pathway →	+0.070	+3.207	<.001	<.001	3	8
URINARY_TRACT	Proximal/distal pattern formation →	+1.020	+3.504	.005	<.001	2	8
BONE	Purine nucleobase catabolic process →	+0.987	+2.834	<.001	<.001	3	7
BONE	Negative regulation of cell-substrate junction organization →	+0.128	+2.445	.002	.003	3	7
BONE	Regulation of ERBB signaling pathway →	+0.073	+2.970	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,674 associations by consensus.

Embryonic skeletal joint morphogenesis by HOXA9 expression — SKIN

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