HOXA7

Across TCGA cell cohorts, HOXA7 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HOXA7-associated genes across cancer lineages are OR1L1, CBLL2, and IQCF2. Each is linked with HOXA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA7-to-partner and partner-to-HOXA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by HOXA7-low versus HOXA7-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA7→partner) and Y-score (partner→HOXA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L1 →	+0.036	+5.196	<.001	.005	3	1
OVARY	CBLL2 →	+0.036	+5.196	<.001	.005	3	1
OVARY	IQCF2 →	+0.055	+5.196	<.001	.005	3	1
OVARY	ODF4 →	+0.042	+5.196	<.001	.005	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR1L1 by HOXA7 expression — OVARY

Explore this box plot interactively →