HOXA7

Across TCGA pan-cancer cohorts, HOXA7 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HOXA7 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HOXA7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXA7 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

UCEC, KIRC, and LGG are the cancer types where HOXA7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.897	0.954	<.001	80	view →
KIRC	DFS	Median	All	0.787	0.472	<.001	68	view →
LGG	DFS	Median	All	0.260	0.555	<.001	54	view →
LAML	DFS	Tertile	All	0.265	0.614	<.001	48	view →
READ	DFS	Tertile	II,III,IV	0.195	0.633	.002	25	view →
CESC	DFS	Tertile	III,IV	0.497	0.846	.014	18	view →
LIHC	DFS	Quartile	II,III,IV	0.358	0.131	.008	18	view →
SCLC	OS	Quartile	II,III,IV	0.885	0.526	.020	16	view →
OV	OS	Tertile	II,III,IV	0.787	0.895	.025	16	view →
COAD	OS	Tertile	All	0.837	0.638	.014	15	view →
STAD	DFS	Median	II,III,IV	0.582	0.800	.005	12	view →
SKCM	OS	Tertile	IV	0.833	0.414	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HOXA7–UCEC (OS)

Open the UCEC breakdown →