HOXA6

Across TCGA pan-cancer cohorts, HOXA6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HOXA6 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HOXA6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HOXA6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where HOXA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.930	0.449	.004	28	view →
LUAD	OS	Tertile	All	0.563	0.909	.001	26	view →
PDAC	DFS	Median	All	0.713	0.975	.005	18	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.689	.009	15	view →
HNSC	OS	Median	II,III,IV	0.848	0.584	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HOXA6–UCEC (DFS)

Open the UCEC breakdown →