HOXA6

Across TCGA patient cohorts, HOXA6 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA6-associated genes across cancer lineages are Ku80, Notch1, and 14-3-3_beta. Each is linked with HOXA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA6-to-partner and partner-to-HOXA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by HOXA6-low versus HOXA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA6→partner) and Y-score (partner→HOXA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.252	+2.128	.014	.010	3	2
UCEC	Notch1 →	+0.286	+3.598	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.109	-3.295	.013	.009	3	1
UCEC	JNK2 →	+0.179	+2.179	.039	.034	3	1
UCEC	MSH2 →	-0.340	-3.295	<.001	.009	3	1
UCEC	MSH6 →	-0.381	-2.449	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Ku80 by HOXA6 expression — UCEC

Explore this box plot interactively →