HOXA6

Across TCGA cell cohorts, HOXA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,425 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HOXA6-associated GO terms across cancer lineages are Protein stabilization, Regulation of syncytium formation by plasma membrane fusion, and RNA localization. Each is linked with HOXA6 in more than 9 cancer types. Because this analysis shows association rather than direction, both HOXA6-to-partner and partner-to-HOXA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein stabilization grouped by HOXA6-low versus HOXA6-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA6→partner) and Y-score (partner→HOXA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Protein stabilization →	+0.045	+1.755	<.001	<.001	3	10
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.070	+1.248	.008	.002	3	9
LARGE_INTESTINE	RNA localization →	+0.075	+1.749	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.088	+0.708	.001	.007	3	9
BREAST	Regulation of cell-substrate junction organization →	+0.085	+0.964	<.001	<.001	3	9
SKIN	Regulation of myoblast fusion →	+0.078	+0.821	<.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,425 associations by consensus.

Protein stabilization by HOXA6 expression — LARGE_INTESTINE

Explore this box plot interactively →