HOXA5

Across TCGA patient cohorts, HOXA5 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA5-associated genes across cancer lineages are ATM, Tuberin_pT1462, and Bcl-2. Each is linked with HOXA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA5-to-partner and partner-to-HOXA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HOXA5-low versus HOXA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA5→partner) and Y-score (partner→HOXA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.513	-3.000	.039	.036	3	2
UCEC	Tuberin_pT1462 →	+0.386	+3.009	.002	.019	3	1
UCEC	Bcl-2 →	-0.472	-3.143	.013	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+1.010	+3.169	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by HOXA5 expression — UCEC

Explore this box plot interactively →