HOXA5

Across TCGA pan-cancer cohorts, HOXA5 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated HOXA5 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HOXA5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXA5 expression acts as an unfavorable survival marker, although some lineages such as ACC and COAD show a favorable association.

UCEC, CESC, and LGG are the cancer types where HOXA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.894	0.957	<.001	116	view →
CESC	DFS	Median	All	0.656	0.818	<.001	66	view →
LGG	DFS	Median	All	0.625	0.837	<.001	54	view →
ACC	DFS	Median	III,IV	0.826	0.290	.001	43	view →
LAML	DFS	Quartile	All	0.492	0.800	<.001	40	view →
READ	DFS	Tertile	All	0.682	0.892	.003	26	view →
COAD	DFS	Median	IV	0.613	0.339	.001	25	view →
KIRC	DFS	Quartile	All	0.901	0.812	.005	23	view →
THCA	OS	Median	II,III,IV	0.961	0.992	.009	23	view →
HNSC	DFS	Quartile	IV	0.787	0.430	.003	20	view →
SKCM	DFS	Median	All	0.663	0.572	.004	18	view →
OV	OS	Quartile	All	0.767	0.886	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

HOXA5–UCEC (OS)

Open the UCEC breakdown →