HOXA5

Across TCGA cell cohorts, HOXA5 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXA5-associated genes across cancer lineages are BTBD16, CRYAA, and OR10K2. Each is linked with HOXA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA5-to-partner and partner-to-HOXA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD16 grouped by HOXA5-low versus HOXA5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA5→partner) and Y-score (partner→HOXA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BTBD16 →	+0.065	+3.959	.003	.005	3	1
BLOOD_Leukemia	CRYAA →	+0.044	+3.705	.007	.007	3	1
BLOOD_Leukemia	OR10K2 →	+0.047	+3.705	<.001	.007	3	1
BLOOD_Leukemia	TBPL2 →	+0.134	+4.044	<.001	.004	3	1
BLOOD_Leukemia	OR10T2 →	+0.895	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	OR10R2 →	+1.904	+4.966	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

BTBD16 by HOXA5 expression — BLOOD_Leukemia

Explore this box plot interactively →