HOXA3

Across TCGA cell cohorts, HOXA3 mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXA3-associated genes across cancer lineages are SIGLEC5, OR5B12, and CLDN8. Each is linked with HOXA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA3-to-partner and partner-to-HOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by HOXA3-low versus HOXA3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA3→partner) and Y-score (partner→HOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIGLEC5 →	+0.060	+3.817	<.001	.004	3	2
LUNG_SCLC	OR5B12 →	+0.034	+3.523	.008	.008	3	2
BLOOD_Leukemia	CLDN8 →	+0.012	+4.234	<.001	.003	3	2
LARGE_INTESTINE	CHCHD1 →	+0.654	+3.404	<.001	<.001	3	2
SKIN	ECEL1 →	+0.328	+3.906	<.001	.001	3	2
SOFT_TISSUE	DMRTC2 →	+0.019	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

SIGLEC5 by HOXA3 expression — LUNG_SCLC

Explore this box plot interactively →