HOXA11

Across TCGA cell cohorts, HOXA11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,417 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXA11-associated GO terms across cancer lineages are Embryonic skeletal joint morphogenesis, Embryonic skeletal joint development, and Mesodermal cell fate specification. Each is linked with HOXA11 in more than 13 cancer types. Because this analysis shows association rather than direction, both HOXA11-to-partner and partner-to-HOXA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic skeletal joint morphogenesis grouped by HOXA11-low versus HOXA11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA11→partner) and Y-score (partner→HOXA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Embryonic skeletal joint morphogenesis →	-0.271	-1.908	<.001	<.001	3	14
BONE	Embryonic skeletal joint development →	-0.297	-1.926	<.001	<.001	3	11
LARGE_INTESTINE	Mesodermal cell fate specification →	+1.278	+1.610	<.001	<.001	3	10
STOMACH	Embryonic hindgut morphogenesis →	+1.179	+2.077	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Response to testosterone →	-0.139	-0.890	<.001	<.001	3	8
BLOOD_Leukemia	Hindgut development →	+0.489	+1.051	.008	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,417 associations by consensus.

Embryonic skeletal joint morphogenesis by HOXA11 expression — BONE

Explore this box plot interactively →