HOXA11-AS

Across TCGA pan-cancer cohorts, HOXA11-AS RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HOXA11-AS data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HOXA11-AS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXA11-AS expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

KIRP, ACC, and MESO are the cancer types where HOXA11-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.515	0.819	<.001	133	view →
ACC	OS	Median	All	0.418	0.834	<.001	102	view →
MESO	DFS	Median	All	0.257	0.462	<.001	79	view →
KIRC	DFS	Tertile	All	0.821	0.935	.003	65	view →
COAD	OS	Tertile	II,III,IV	0.748	0.284	.001	64	view →
LGG	OS	Median	All	0.338	0.544	<.001	51	view →
UVM	OS	Median	All	0.598	0.827	.001	47	view →
HNSC	DFS	Quartile	All	0.538	0.726	.001	29	view →
OV	DFS	Tertile	All	0.496	0.606	.004	26	view →
PAAD	DFS	Tertile	All	0.196	0.422	.006	25	view →
LIHC	OS	Median	All	0.449	0.684	<.001	21	view →
CESC	DFS	Median	All	0.472	0.604	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HOXA11-AS–KIRP (OS)

Open the KIRP breakdown →