HOXA11-AS

Across TCGA pan-cancer cohorts, HOXA11-AS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HOXA11-AS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXA11-AS RNA is repressed in tumor relative to normal tissue. In most cancer types HOXA11-AS is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where HOXA11-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA11-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.108	<.001	11	view →
HNSC	Male	All	+0.491	<.001	11	view →
LUAD	All	III,IV	+0.540	<.001	9	view →
STAD	Male	II,III,IV	+1.668	<.001	8	view →
BLCA	Male	III,IV	−1.801	<.001	7	view →
LUSC	All	All	+0.861	<.001	6	view →
THCA	All	III,IV	+0.115	<.001	6	view →
BRCA	Female	II,III,IV	+0.178	.002	4	view →
PRAD	All	All	+0.732	.002	2	view →
LIHC	All	All	+0.234	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HOXA11-AS–KIRC

Open the KIRC breakdown →