HOXA10

Across TCGA patient cohorts, HOXA10 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA10-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and STAT3_pY705. Each is linked with HOXA10 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXA10-to-partner and partner-to-HOXA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HOXA10-low versus HOXA10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA10→partner) and Y-score (partner→HOXA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.635	-2.986	.010	.035	3	3
UCEC	JNK_pT183_Y185 →	-0.225	-3.000	.014	.036	3	1
UCEC	STAT3_pY705 →	-0.504	-2.990	<.001	.036	3	1
UCEC	p62 Lck ligand →	+0.419	+2.817	.019	.036	2	1
UCEC	Tuberin →	+0.373	+2.817	.011	.036	2	1
UCEC	PCNA →	+0.311	+3.169	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ATM by HOXA10 expression — UCEC

Explore this box plot interactively →