HOXA-AS3

Across TCGA pan-cancer cohorts, HOXA-AS3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HOXA-AS3 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HOXA-AS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXA-AS3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

UCEC, READ, and LGG are the cancer types where HOXA-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.893	0.958	<.001	86	view →
READ	DFS	Quartile	All	0.600	0.887	<.001	57	view →
LGG	DFS	Median	All	0.599	0.845	<.001	54	view →
LAML	DFS	Tertile	All	0.294	0.605	<.001	40	view →
HNSC	DFS	Tertile	IV	0.803	0.393	<.001	37	view →
CESC	DFS	Tertile	III,IV	0.568	0.867	.003	34	view →
BRCA	OS	Tertile	IV	0.484	0.959	.002	29	view →
COAD	OS	Tertile	IV	0.760	0.351	.001	27	view →
KIRC	DFS	Median	All	0.863	0.719	.003	26	view →
OV	OS	Median	II,III,IV	0.795	0.883	.012	22	view →
ACC	OS	Quartile	III,IV	0.893	0.362	.016	18	view →
LIHC	OS	Quartile	All	0.601	0.745	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HOXA-AS3–UCEC (OS)

Open the UCEC breakdown →