HOXA-AS3

Across TCGA pan-cancer cohorts, HOXA-AS3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HOXA-AS3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXA-AS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXA-AS3 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, KIRP, and THCA are the cancer types where HOXA-AS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA-AS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.209	<.001	9	view →
KIRP	All	All	+0.375	.012	7	view →
THCA	All	II,III,IV	−0.013	.001	7	view →
BRCA	All	All	−0.570	<.001	6	view →
KICH	All	All	−0.511	<.001	6	view →
UCEC	All	II,III,IV	+1.036	.007	4	view →
BLCA	All	All	+0.371	.012	4	view →
STAD	Male	II,III,IV	+0.324	.010	4	view →
CHOL	All	All	+0.297	.005	4	view →
LUSC	All	All	+0.240	.001	4	view →
KIRC	All	II,III,IV	−0.183	.008	3	view →
LIHC	All	All	+0.049	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HOXA-AS3–HNSC

Open the HNSC breakdown →