HORMAD1

Across TCGA patient cohorts, HORMAD1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HORMAD1-associated genes across cancer lineages are ASNS, eIF4E, and Annexin-1. Each is linked with HORMAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HORMAD1-to-partner and partner-to-HORMAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HORMAD1-low versus HORMAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HORMAD1→partner) and Y-score (partner→HORMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.474	+3.169	.001	.018	3	3
UCEC	eIF4E →	+0.202	+3.459	.023	.005	3	2
UCEC	Annexin-1 →	+0.442	+2.189	.048	.034	3	2
UCEC	FASN →	+0.404	+3.169	.015	.019	3	1
UCEC	MEK1 →	+0.448	+2.584	.003	.010	3	1
UCEC	p62 Lck ligand →	+0.523	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ASNS by HORMAD1 expression — UCEC

Explore this box plot interactively →