HORMAD1

Across TCGA pan-cancer cohorts, HORMAD1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HORMAD1 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HORMAD1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HORMAD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

HNSC, KIRC, and LGG are the cancer types where HORMAD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.676	0.344	.001	70	view →
KIRC	OS	Median	All	0.515	0.697	<.001	60	view →
LGG	DFS	Median	All	0.333	0.455	<.001	42	view →
THCA	DFS	Median	III,IV	0.765	0.947	.003	40	view →
READ	DFS	Tertile	II,III,IV	0.746	0.224	<.001	32	view →
ESCA	DFS	Median	All	0.927	0.454	.004	21	view →
UCS	DFS	Quartile	III,IV	0.460	0.155	.008	16	view →
LUAD	DFS	Quartile	IV	0.817	0.292	.008	12	view →
LAML	DFS	Tertile	All	0.465	0.761	.028	12	view →
PAAD	OS	Quartile	II,III,IV	0.771	0.484	.015	11	view →
SCLC	OS	Tertile	IV	0.205	0.587	.049	9	view →
SKCM	DFS	Quartile	All	0.332	0.156	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HORMAD1–HNSC (DFS)

Open the HNSC breakdown →