HOPX

Across TCGA pan-cancer cohorts, HOPX mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HOPX data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HOPX mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HOPX expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where HOPX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	1.000	0.733	.004	35	view →
CCRCC	OS	Tertile	IV	0.198	0.830	.024	18	view →
PDAC	DFS	Tertile	III,IV	0.864	0.352	.009	15	view →
GBM	DFS	Quartile	All	0.910	0.684	.012	11	view →
LSCC	DFS	Median	All	0.980	0.899	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HOPX–HNSC (OS)

Open the HNSC breakdown →