HOOK3

Across TCGA patient cohorts, HOOK3 mutation is significantly associated with the RNA expression of many other genes, with 1,922 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOOK3-associated genes across cancer lineages are GAGE2E, ALDH7A1P4, and MIR548S. Each is linked with HOOK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOOK3-to-partner and partner-to-HOOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE2E grouped by HOOK3-low versus HOOK3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK3→partner) and Y-score (partner→HOOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAGE2E →	+0.129	+5.649	<.001	.001	3	2
LUAD	ALDH7A1P4 →	+0.124	+4.263	<.001	.007	3	2
LUAD	MIR548S →	+0.388	+3.458	.002	.003	3	2
BLCA	RNU6-406P →	+0.565	+4.178	.002	.009	3	2
SKCM	RPS24P1 →	+0.535	+4.385	<.001	.008	3	2
SKCM	MIR6076 →	+0.416	+3.730	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,922 associations by consensus.

GAGE2E by HOOK3 expression — BRCA

Explore this box plot interactively →