HOOK2

Across TCGA patient cohorts, HOOK2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,748 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HOOK2-associated genes across cancer lineages are HIC1, FYN, and SH2D4A. Each is linked with HOOK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both HOOK2-to-partner and partner-to-HOOK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOOK2 versus HIC1 in OV, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK2→partner) and Y-score (partner→HOOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HIC1 →	-0.946	-0.417	<.001	<.001	3	7
UCEC	FYN →	-0.737	-0.290	.001	<.001	3	7
BRCA	SH2D4A →	+1.014	+0.256	<.001	<.001	3	6
UCEC	CRB3 →	+0.817	+0.236	.004	<.001	3	6
UCEC	SLC16A1-AS1 →	-0.812	-0.368	<.001	<.001	3	6
BRCA	IL21R →	-0.780	-0.330	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,748 associations by consensus.

HOOK2 vs HIC1 — OV

Explore this scatter interactively →