HOOK2

Across TCGA cell cohorts, HOOK2 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOOK2-associated genes across cancer lineages are OR4F21, KHDC3L, and OR7A10. Each is linked with HOOK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOOK2-to-partner and partner-to-HOOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F21 grouped by HOOK2-low versus HOOK2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK2→partner) and Y-score (partner→HOOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4F21 →	+0.060	+4.096	.001	.001	3	2
BLOOD_Leukemia	KHDC3L →	+0.154	+2.829	<.001	.005	3	2
BREAST	OR7A10 →	+0.010	+4.781	<.001	.003	3	1
SKIN	GALR1 →	+0.972	+5.022	<.001	.002	3	1
SKIN	C4orf50 →	+0.028	+4.684	<.001	.002	3	1
SKIN	RGS21 →	+0.018	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

OR4F21 by HOOK2 expression — CNS

Explore this box plot interactively →