HOOK1

Across TCGA patient cohorts, HOOK1 mutation is significantly associated with the RNA expression of many other genes, with 2,658 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOOK1-associated genes across cancer lineages are RNU6-1054P, COX15, and TMCO3. Each is linked with HOOK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOOK1-to-partner and partner-to-HOOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1054P grouped by HOOK1-low versus HOOK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOOK1→partner) and Y-score (partner→HOOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1054P →	+0.425	+4.299	.003	.007	3	3
UCEC	COX15 →	+0.472	+2.860	<.001	.001	3	2
UCEC	TMCO3 →	+0.596	+2.502	<.001	.001	3	2
UCEC	FAM177A1 →	+0.314	+2.032	.002	.004	3	2
UCEC	USP12 →	+0.360	+1.515	.008	.006	3	2
UCEC	GPR180 →	+0.563	+2.378	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,658 associations by consensus.

RNU6-1054P by HOOK1 expression — BLCA

Explore this box plot interactively →